[1]孫 瑩,王惠萍,段麗芬,等.小兒智力糖漿聯合阿立哌唑治療兒童抽動障礙的療效及其對免疫功能的影響[J].醫學信息,2019,(20):139-141.[doi:10.3969/j.issn.1006-1959.2019.20.043]
 SUN Ying,WANG Hui-ping,DUAN Li-fen,et al.Therapeutic Effect of Pediatric Intellectual Syrup Combined with Aripiprazole on Children with Tic Disorder and its Effect on Immune Function[J].Medical Information,2019,(20):139-141.[doi:10.3969/j.issn.1006-1959.2019.20.043]
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小兒智力糖漿聯合阿立哌唑治療兒童抽動障礙的療效及其對免疫功能的影響()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年20期
頁碼:
139-141
欄目:
藥物與臨床
出版日期:
2019-10-15

文章信息/Info

Title:
Therapeutic Effect of Pediatric Intellectual Syrup Combined with Aripiprazole on Children with Tic Disorder and its Effect on Immune Function
文章編號:
1006-1959(2019)20-0139-03
作者:
孫 瑩王惠萍段麗芬王春霞張 霞鄭宇霞王左華羅 超
(云南省昆明市兒童醫院神經內科,云南 昆明 650034)
Author(s):
SUN YingWANG Hui-pingDUAN Li-fenWANG Chun-xiaZHANG XiaZHENG Yu-xiaWANG Zuo-huaLUO Chao
(Department of Neurology,Children's Hospital of Kunming,Kunming 650034,Yunnan,China)
關鍵詞:
小兒智力糖漿阿立哌唑兒童抽動障礙免疫功能
Keywords:
Children's intelligence syrupAripiprazoleChildren with tic disorderImmune function
分類號:
R749.94
DOI:
10.3969/j.issn.1006-1959.2019.20.043
文獻標志碼:
A
摘要:
目的 探究小兒智力糖漿聯合阿立哌唑治療兒童抽動障礙的臨床療效及其對兒童免疫功能的影響。方法 選擇我院兒科2017年1月~2018年1月收治的64例抽動障礙患兒作為研究對象,按照隨機數字表法分為觀察組和對照組,各32例。對照組采用阿立哌唑治療,觀察組在對照組基礎上聯合小兒智力糖漿治療,比較兩組患兒外周T淋巴細胞亞群及血清免疫球蛋白(Ig)水平、耶魯綜合抽動嚴重程度量表評分(YGTSS)、注意力缺陷多動障礙評分量表評分(ADHD)及臨床療效。結果 觀察組運動抽動、發聲抽動、功能受損程度及抽動總分均低于對照組,差異有統計學意義(P<0.05);觀察組注意力缺陷、多動沖動及ADHD總分低于對照組,差異有統計學意義(P<0.05);觀察組治療總有效率為96.87%,高于對照組的75.00%,差異有統計學意義(P<0.05);觀察組外周血CD3、CD4、CD4/CD8、IgG及IgA均高于對照組,差異具有統計學意義(P<0.05);兩組外周血CD8及IgM比較,差異無統計學意義(P>0.05)。結論 小兒智力糖漿聯合阿立哌唑可有效改善兒童抽動障礙的臨床癥狀和免疫功能,效果優于單用阿立哌唑,臨床療效確切。
Abstract:
Objective To investigate the clinical efficacy of pediatric intellectual syrup combined with aripiprazole in the treatment of children with tic disorder and its effect on children's immune function. Methods 64 children with tic disorder admitted to our hospital from January 2017 to January 2018 were enrolled in the study. According to the random number table, the observation group and the control group were divided into 32 cases. The control group was treated with aripiprazole. The observation group was treated with pediatric intellectual syrup on the basis of the control group. The peripheral fasting blood was taken to detect the peripheral T lymphocyte subsets and serum immunoglobulin (Ig) levels.The Yale Comprehensive Tic Severity Scale Scale (YGTSS), Attention Deficit Hyperactivity Disorder Rating Scale (ADHD) and clinical outcome were compared between two groups. Results The twitching, vocal twitching, functional impairment and twitching scores of the observation group were lower than the control group,the difference was statistically significant (P<0.05). The attention deficit, hyperactivity impulse and total ADHD scores in the observation group were lower than the control group,the difference was statistically significant (P<0.05). The total effective rate of the observation group was 96.87%, which was higher than that of the control group 75.00%,the difference was statistically significant (P<0.05). The peripheral blood CD3, CD4, CD4/CD8, IgG and IgA were higher than the control group, the difference was statistically significant (P<0.05). There was no significant difference in CD8 and IgM between the two groups (P>0.05). Conclusion Infant intelligence syrup combined with aripiprazole can effectively improve the clinical symptoms and immune function of children with tic disorder. The effect is better than aripiprazole alone. The clinical effect is exact.

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相似文獻/References:

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更新日期/Last Update: 2019-10-15
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