[1]李欽濤.不同劑量肝素在血液灌流治療農藥中毒中的應用[J].醫學信息,2019,(20):110-111.[doi:10.3969/j.issn.1006-1959.2019.19.032]
 LI Qin-tao.Application of Different Doses of Heparin in the Treatment of Pesticide Poisoning by Blood Perfusion[J].Medical Information,2019,(20):110-111.[doi:10.3969/j.issn.1006-1959.2019.19.032]
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不同劑量肝素在血液灌流治療農藥中毒中的應用()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年20期
頁碼:
110-111
欄目:
臨床研究
出版日期:
2019-10-15

文章信息/Info

Title:
Application of Different Doses of Heparin in the Treatment of Pesticide Poisoning by Blood Perfusion
文章編號:
1006-1959(2019)19-0110-02
作者:
李欽濤
(東阿縣人民醫院重癥醫學科,山東 東阿 252200)
Author(s):
LI Qin-tao
(Department of ICU,Dong'e County People's Hospital,Dong'e 252200,Shandong,China)
關鍵詞:
血液灌流中毒肝素
Keywords:
Blood perfusionPoisoningHeparin
分類號:
R472
DOI:
10.3969/j.issn.1006-1959.2019.19.032
文獻標志碼:
A
摘要:
目的 分析血液灌流治療農藥中毒中肝素的用量。方法 選取2017年1月~2018年12月我院重癥醫學科收治的農藥中毒患者116例,按照肝素使用劑量的不同分成兩組,其中采用首劑量0.5 mg/kg者63例設為A組,采用首劑量8 mg/kg者53例設為B組,比較兩組不同時間段血小板計數、APTT指標以及出血發生率。結果 兩組治療前及治療后24、48、72 h血小板計數指標比較,差異均無統計學意義(P>0.05);治療后4 h,B組血小板計數為(150.92±23.83)×109/L,低于A組的(178.73±39.18)×109/L,差異有統計學意義(P<0.05);兩組治療前后48、72 h APTT比較,差異均無統計學意義(P>0.05);治療后A組4、24 h APTT較B組延長,差異有統計學意義(P<0.05);B組出血發生率為5.67%,低于A組的22.22%,差異有統計學意義(P<0.05)。結論 農藥中毒患者血液灌流治療中肝素首劑量采用8 mg/kg,效果較好,對血液抗凝效果較好,出血率低。
Abstract:
Objective To analyze the amount of heparin in the treatment of pesticide poisoning by blood perfusion.Methods A total of 116 patients with pesticide poisoning admitted to our Department of Critical Care Medicine from January 2017 to December 2018 were enrolled. The patients were divided into two groups according to the dose of heparin. There were 63 patients in group A and 53 patients in group B. The first dose was 0.5 mg. The patients with /kg were set to group A, and the first dose of 8 mg/kg was used as group B. The platelet count, APTT index and bleeding rate were compared between the two groups. Results There were no significant differences in platelet counts between the two groups before treatment and at 24, 48, and 72 h after treatment (P>0.05). At 4 h after treatment, the platelet count of group B was (150.92±23.83)×109/L,below the group A (178.73 ± 39.18) × 109/L,the difference was statistically significant (P<0.05). There was no significant difference in APTT between the two groups at 48 and 72 h before and after treatment (P>0.05). After treatment, the APTT at 4 and 24 h in group A was longer than that in group B,the difference was statistically significant (P<0.05). The incidence of bleeding in group B was 5.67%, which was lower than 22.22% in group A,the difference was statistically significant (P<0.05).Conclusion In the treatment of patients with pesticide poisoning, the first dose of heparin in the treatment of blood perfusion is 8 mg/kg, the effect is better, the anticoagulation effect on blood is better, and the bleeding rate is lower.

參考文獻/References:

[1]趙國紅.對急性重度有機磷農藥中毒患者進行血液灌流治療的效果分析[J].當代醫藥論叢,2016,14(10):163-164. [2]孫艷紅,王克民.依諾肝素鈉抗凝在急性中毒血液灌流中的臨床分析[J].系統醫學,2018,3(21):53-55. [3]李紅英,熊偉.維持性血液透析患者血液灌流凝血原因分析及護理進展[J].中國現代藥物應用,2018,12(18):215-216. [4]楊素云,劉曉彬.高濃度肝素鹽水封管對急性重度中毒患者血液灌流期間導管堵塞及出血風險的影響[J].國際檢驗醫學雜志,2018,39(15):1824-1826,1831. [5]張海鋼,吳京蘭,黃鐳,等.局部枸櫞酸抗凝在重癥中毒患者血液灌流治療中的應用研究[J].中國血液凈化,2018,17(4):217-221.

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更新日期/Last Update: 2019-10-15
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