[1]華啟洋,吳同利,劉永艷,等.幽門螺桿菌在胃食管反流病發病中的作用[J].醫學信息,2019,(20):103-104,107.[doi:10.3969/j.issn.1006-1959.2019.20.029]
 HUA Qi-yang,WU Tong-li,LIU Yong-yan,et al.The Role of Helicobacter Pylori in the Pathogenesis of Gastroesophageal Reflux Disease[J].Medical Information,2019,(20):103-104,107.[doi:10.3969/j.issn.1006-1959.2019.20.029]
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幽門螺桿菌在胃食管反流病發病中的作用()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年20期
頁碼:
103-104,107
欄目:
臨床研究
出版日期:
2019-10-15

文章信息/Info

Title:
The Role of Helicobacter Pylori in the Pathogenesis of Gastroesophageal Reflux Disease
文章編號:
1006-1959(2019)20-0103-03
作者:
華啟洋吳同利劉永艷孫鳳芹姚 燕
(昆山市第四人民醫院消化科,江蘇 昆山 215331)
Author(s):
HUA Qi-yangWU Tong-liLIU Yong-yanSUN Feng-qinYAO Yan
(Department of Gastroenterology,Kunshan Fourth People's Hospital,Kunshan 215331,Jiangsu,China)
關鍵詞:
胃食管反流病幽門螺桿菌慢性胃炎
Keywords:
Gastroesophageal reflux diseaseHelicobacter pyloriChronic gastritis
分類號:
R573
DOI:
10.3969/j.issn.1006-1959.2019.20.029
文獻標志碼:
A
摘要:
目的 探討幽門螺桿菌(Hp)在胃食管反流病(GERD)發病中的作用,為臨床診治GERD提供參考。方法 選取2016年 2月~2018年12月我院收治的胃食管反流病患者85例,設為GERD組,另選同期我院體檢健康者30人為對照組,14C呼氣試驗法進行Hp檢測,比較兩組Hp感染陽性率、GERD不同癥狀程度者Hp感染陽性率以及反流性食管炎(RE)不同程度者Hp感染陽性率。結果 GERD組Hp感染陽性率(54.12%)高于對照組(46.67%),差異無統計學意義(P>0.05);GERD輕度癥狀組、中度癥狀組、重度癥狀組及極重度癥狀組Hp感染陽性率分別為55.00%、52.00%、54.55%、55.56%,組間比較,差異無統計學意義(P>0.05);RE患者LA-A組、LA-B組、LA-C組及LA-D組Hp感染陽性率分別是57.14%、55.56%、47.06%、46.15%,組間比較差異無統計學意義(P>0.05)。結論 幽門螺桿菌感染在胃食管反流病發生和發展過程中可能無相關性,但對于Hp陽性的GERD患者也應根據實際情況實施根除Hp治療,以減少惡變幾率。
Abstract:
Objective To investigate the role of Helicobacter pylori (Hp) in the pathogenesis of gastroesophageal reflux disease (GERD) and provide reference for clinical diagnosis and treatment of GERD.Methods 85 patients with gastroesophageal reflux disease admitted to our hospital from February 2016 to December 2018 were enrolled in the GERD group. Another 30 healthy people in our hospital were selected as the control group, and the 14C breath test method was used for Hp detection. The positive rate of Hp infection, the positive rate of Hp infection in different degrees of GERD, and the positive Hp infection in different degrees of RE were compared between the two groups.Results The positive rate of Hp infection in GERD group (54.12%) was higher than that in control group (46.67%), the difference was not statistically significant (P>0.05); GERD mild symptom group, moderate symptom group, severe symptom group and very severe symptom group Hp the positive rates of infection were 55.00%, 52.00%, 54.55%, and 55.56%, respectively. There was no significant difference between the groups (P>0.05).The positive rates of Hp infection in LA-A group, LA-B group, LA-C group and LA-D group were 57.14%, 55.56%, 47.06%, and 46.15%, respectively. There was no significant difference between the groups (P>0.05).Conclusion Helicobacter pylori infection may not be associated with the development and progression of gastroesophageal reflux disease. However, patients with Hp-positive GERD should also be treated with Hp eradication according to the actual situation to reduce the risk of malignant transformation.

參考文獻/References:

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更新日期/Last Update: 2019-10-15
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