[1]李肖亮,陳 科,莫 非,等.腦干出血急性期氧化應激及炎性反應的相關性[J].醫學信息,2019,(20):60-62,66.[doi:10.3969/j.issn.1006-1959.2019.20.017]
 LI Xiao-liang,CHEN Ke,MO Fei,et al.Correlation between Oxidative Stress and Inflammatory Response in Acute Stage of Brain Stem Hemorrhage[J].Medical Information,2019,(20):60-62,66.[doi:10.3969/j.issn.1006-1959.2019.20.017]
點擊復制

腦干出血急性期氧化應激及炎性反應的相關性()
分享到:

醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年20期
頁碼:
60-62,66
欄目:
論著
出版日期:
2019-10-15

文章信息/Info

Title:
Correlation between Oxidative Stress and Inflammatory Response in Acute Stage of Brain Stem Hemorrhage
文章編號:
1006-1959(2019)20-0060-04
作者:
李肖亮陳 科莫 非劉傳明楊 鵬
(空軍軍醫大學第一附屬醫院急診科,陜西 西安 710032)
Author(s):
LI Xiao-liangCHEN KeMO FeiLIU Chuan-mingYANG Peng
(Department of Emergency,the First Affiliated Hospital of Air Force Military Medical University, Xi'an 710032,Shaanxi,China)
關鍵詞:
腦干出血炎性指標氧化應激急診救治預后
Keywords:
Brain stem hemorrhageInflammatory indexOxidative stressEmergency treatmentPrognosis
分類號:
R743.34
DOI:
10.3969/j.issn.1006-1959.2019.20.017
文獻標志碼:
A
摘要:
目的 探討腦干出血急性期氧化應激和炎性反應的相關性。方法 收集2015年10月~2018年10月我院收治的腦干出血患者46例,依照中國腦出血診療指導規范分為死亡組(25例)和生存組(21例)。比較兩組天門冬氨酸轉氨酶(AST)、丙氨酸氨基轉移酶(ALT)、肌酐(CR)、尿素氮(BUN)、白細胞計數(WBC)、降鈣素原(PCT)、白介素6(IL-6)、血乳酸、中性粒細胞計數、鈉離子(Na)、鉀離子(K)、鈣離子(Ca)、乳酸脫氫酶(LDH)、肌酸激酶同工酶(CK-MB)、腦干出血量,分析腦干出血后氧化應激及炎性反應的相關性。結果 兩組CR、BUN、PCT、Na、K、Ca、LDH、CK-MB、腦干出血量比較,差異無統計學意義(P>0.05);兩組AST、ALT、WBC、中性粒細胞計數、IL-6比較,差異有統計學意義(P<0.05)。Spearman相關性分析結果顯示,WBC、中性粒細胞計數、血乳酸、IL-6、AST、ALT與腦干出血后氧化應激呈正相關(P<0.05)。多元線性Logistic回歸結果顯示,WBC、中性粒細胞計數、血乳酸水平、IL-6是腦干出血后氧化應激的獨立危險因素。結論 WBC、中性粒細胞計數、血乳酸水平、IL-6是腦干出血后氧化應激的獨立危險因素,可用于腦干出血急診的早期發現和干預,從而提高腦干出血急診救治成功率,進一步降低死亡率和致殘率。
Abstract:
Objective To investigate the correlation between oxidative stress and inflammatory response in the acute phase of brain stem hemorrhage. Methods 46 patients with brain stem hemorrhage admitted to our hospital from October 2015 to October 2018 were enrolled. According to the guidelines for diagnosis and treatment of cerebral hemorrhage in China, they were divided into death group (25 cases) and survival group (21 cases). Comparison of two groups of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (CR), urea nitrogen (BUN), white blood cell count (WBC), procalcitonin (PCT), interleukin 6 ( IL-6), blood lactate, neutrophil count, sodium ion (Na), potassium ion (K), calcium ion (Ca), lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB ), the amount of brain stem bleeding, analysis of the correlation between oxidative stress and inflammatory response after brain stem hemorrhage. Results There were no significant differences in CR, BUN, PCT, Na, K, Ca, LDH, CK-MB, and brain stem bleeding between the two groups (P>0.05). AST, ALT, WBC, and neutrophil counts in the two groups. Compared with IL-6, the difference was statistically significant (P<0.05). Spearman correlation analysis showed that WBC, neutrophil count, blood lactate, IL-6, AST, ALT were positively correlated with oxidative stress after brain stem hemorrhage (P<0.05). Multivariate linear logistic regression showed that WBC, neutrophil count, blood lactate level, and IL-6 were independent risk factors for oxidative stress after brain stem hemorrhage.Conclusion WBC, neutrophil count, blood lactate level and IL-6 are independent risk factors for oxidative stress after brain stem hemorrhage. They can be used for early detection and intervention of emergency treatment of brain stem hemorrhage, thus improving the success rate of emergency treatment of brain stem hemorrhage. To further reduce mortality and disability.

參考文獻/References:

[1]楊樹源,張建寧.神經外科學[M].北京:人民衛生出版社,2015. [2]中華醫學會神經病學分會.中國腦出血診治指南[J].中華神經科雜志,2015,48(6):435-444. [3]Murakami M,Fujioka S,Oyama T,et al.Serial changes in the regional cerebral blood flow of patients with hypertensive intracerebral hemorrhage:long-term follow-up SPECT study[J].J Neurosurg Sci,2015,49(3):117-124. [4]Ordónez-Rubiano EG,Johnson JM,Younus I,et al.Recovery of consciousness after a brainstem cavernous malformation hemorrhage:A descriptive study of preserved reticular activating system with tractography[J].Journal of Clinical Neuroscience,2019(59):372-377. [5]Lekic T,Rolland W,Manaenko A,et al.Evaluation of the hematoma consequences,neurobehavioral profiles,and histopathology in a rat model of pontine hemorrhage[J].J Neurosurg,2013,118(2):465-477. [6]李敬,李穎,郭麗娟,等.腦干出血并發腦心綜合征心律失常與兒茶酚胺濃度的臨床分析[J].中國現代醫學雜志,2016,26(23):59-62. [7]Schneider U,Davids A,Brandenburg S,et al.Microglia inflict delayed brain injury after subarachnoid hemorrhage[J].Acta Neuropathol,2015,130(2):215-231. [8]Wakai T,Sakata H,Narasimhan P,et al.Transplantation of neural stem cells that overexpress SOD1 enhances amelioration of intracerebral hemorrhage in mice[J].J Cereb Blood Flow Metab,2014,34(3):203-215. [9]Mewhort HE,Lipon BD,Svystonyuk DA,et al.Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-beta1[J].Am J Physiol Heart Circ Physiol,2016(310):716-724. [10]Zhou F,Jiang Z,Yang B,et al.Magnolol exhibits anti-inflammatory and neuroprotective effects in a rat model of intracerebral haemorrhage[J].Brain Behav Immun,2018(12):28. [11]Erdi F,Keskin F,Esen H,et al.Telmisartan ameliorates oxidative stress and subarachnoid haemorrhage-induced cerebral vasospasm[J].Neurol Res,2016,38(3)626-641. [12]Lin L,Yihao T,Zhou F,et al.Inflammatory regulation by driving microglial M2 polarization:neuroprotective effects of cannabinoid receptor-2 activation in intracerebral hemorrhage[J].Front Immunol,2017(8):112-119. [13]Wei L,Lilin L,Michael C,et al.Intracerebral Hemorrhage Induces Cardiac Dysfunction in Mice Without Primary Cardiac Disease[J].Front Neurol,2018(9):965-973. [14]Okamoto K,Naito I,Fukuda T,et al.Adult moyamoya disease associated with abundant phosphorylated tau accumulation in the brainstem:Report of a case with autopsy findings[J].Neuropathology,2018,38(3):224.

更新日期/Last Update: 2019-10-15
重庆时时开奖号码k线图