[1]李 闖,葉勁松,劉 昕,等.ZBP-89與缺氧信號因子HIF-1α在肝癌細胞中的 相關性研究[J].醫學信息,2019,(15):74-76.[doi:10.3969/j.issn.1006-1959.2019.15.023]
 LI Chuang,YE Jin-song,LIU Xin,et al.Correlation between ZBP-89 and Hypoxia Signaling Factor HIF-1α in Hepatoma Cells[J].Medical Information,2019,(15):74-76.[doi:10.3969/j.issn.1006-1959.2019.15.023]
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ZBP-89與缺氧信號因子HIF-1α在肝癌細胞中的 相關性研究()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年15期
頁碼:
74-76
欄目:
論著
出版日期:
2019-08-01

文章信息/Info

Title:
Correlation between ZBP-89 and Hypoxia Signaling Factor HIF-1α in Hepatoma Cells
文章編號:
1006-1959(2019)15-0074-03
作者:
李 闖葉勁松劉 昕陳小紅劉利平程書榜
廣東省深圳市龍華區人民醫院胃腸外科,廣東 深圳 518000
Author(s):
LI ChuangYE Jin-songLIU XinCHEN Xiao-hongLIU Li-pingCHENG Shu-bang
Department of Gastrointestinal Surgery,People's Hospital of Longhua District,Shenzhen 518000,Guangdong,China
關鍵詞:
肝癌ZBP-89HIF-1α缺氧調控因子
Keywords:
Key words:Liver cancerZBP-89HIF-1αHypoxia regulator
分類號:
R735.7
DOI:
10.3969/j.issn.1006-1959.2019.15.023
文獻標志碼:
A
摘要:
目的 探討ZBP-89在肝癌組織中的表達與缺氧誘導因子HIF-1α的相關性,為證實ZBP-89通過抑制HIF-1α/Notch1信號通路降低肝癌干細胞“干性”提供依據。方法 選擇2016年8月~2018年8月深圳市龍華區人民醫院與深圳市人民醫院肝膽胰外科120例原發性肝癌患者作為研究對象,收集病理標本,采用免疫組化染色方法來檢測肝癌細胞及癌旁組織中ZBP-89、HIF-1α的相關表達,分析二者之間的相關性。結果 ZBP-89在肝癌組織中呈現出低表達狀態,而在癌旁組織中卻呈現出高表達狀態,分別為34.17%、62.50%;ZBP-89在癌旁組織中表達高于肝癌組織(P<0.05)。而在肝癌組織細胞中發現ZBP-89的表達與缺氧信號因子HIF-1α的表達呈負相關(P<0.05)。結論 ZBP-89很可能為肝癌發生、發展過程中一個潛在的抑癌基因,通過抑制HIF-1α/Notch1通路進而抑制肝癌干細胞增殖、增強肝癌干細胞對化療藥物的敏感性,可能是其發揮抑癌效應的重要機制。
Abstract:
Abstract:Objective To investigate the correlation between the expression of ZBP-89 in hepatocarcinoma and the hypoxia-inducible factor HIF-1α, and to provide evidence for ZBP-89 to reduce the "dryness" of liver cancer stem cells by inhibiting HIF-1α/Notch1 signaling pathway.Methods From August 2016 to August 2018, 120 patients with primary liver cancer in the Department of Hepatobiliary Surgery of Shenzhen Longhua District People's Hospital and Shenzhen People's Hospital were selected as subjects. Pathological specimens were collected and immunohistochemical staining was used to detect liver cancer cells. The correlation expressions of ZBP-89 and HIF-1α in adjacent tissues were analyzed, and the correlation between them was analyzed. Results ZBP-89 showed low expression status in liver cancer tissues, but high expression status (41/120, 75/120) in adjacent tissues 34.17%, 62.50%, respectively; ZBP-89 in adjacent tissues the expression was higher than that of liver cancer tissues (P<0.05). The expression of ZBP-89 was negatively correlated with the expression of hypoxia signal factor HIF-1α in hepatocarcinoma cells (P<0.05).Conclusion ZBP-89 is likely to be a potential tumor suppressor gene in the development and progression of hepatocarcinoma. It can inhibit the proliferation of hepatocellular carcinoma stem cells and enhance the sensitivity of liver cancer stem cells to chemotherapeutic drugs by inhibiting HIF-1α/Notch1 pathway. An important mechanism of effect.

參考文獻/References:

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更新日期/Last Update: 2019-08-01
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