[1]紀東華.曲美他嗪治療老年冠心病心力衰竭的療效及其對患者 炎癥因子的影響[J].醫學信息,2019,(13):141-142.[doi:10.3969/j.issn.1006-1959.2019.13.043]
 JI Dong-hua.Efficacy of Trimetazidine in the Treatment of Elderly Patients with Coronary Heart Disease and Its Effect on Inflammatory Factors[J].Medical Information,2019,(13):141-142.[doi:10.3969/j.issn.1006-1959.2019.13.043]
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曲美他嗪治療老年冠心病心力衰竭的療效及其對患者 炎癥因子的影響()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年13期
頁碼:
141-142
欄目:
藥物與臨床
出版日期:
2019-07-01

文章信息/Info

Title:
Efficacy of Trimetazidine in the Treatment of Elderly Patients with Coronary Heart Disease and Its Effect on Inflammatory Factors
文章編號:
1006-1959(2019)13-0141-02
作者:
紀東華
佳木斯市中心醫院心內科,黑龍江 佳木斯 154002
Author(s):
JI Dong-hua
Department of Cardiology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China
關鍵詞:
美托洛爾曲美他嗪冠心病心力衰竭
Keywords:
Key words:MetoprololTrimetazidineCoronary heart diseaseHeart failure
分類號:
R541.6
DOI:
10.3969/j.issn.1006-1959.2019.13.043
文獻標志碼:
A
摘要:
目的 探討美托洛爾聯合曲美他嗪治療老年冠心病心力衰竭的療效。方法 收集我院自2016年8月~2018年9月收治的76例冠心病心力衰竭患者,按隨機數字表法分為觀察組和對照組,各38例。兩組均給予標準化心力衰竭治療方案治療,對照組加服酒石酸美托洛爾片治療,觀察組在對照組基礎上聯合曲美他嗪片治療,比較兩組治療前后超敏C反應蛋白(hs-CRP)、白介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)水平及臨床療效。結果 治療后,兩組hs-CRP、IL-6、TNF-α水平均下降,且觀察組低于對照組,差異有統計學意義(P<0.05),觀察組總有效率為92.11%,高于對照組的73.68%,差異有統計學意義(P<0.05)。結論 美托洛爾聯合曲美他嗪能夠有效提高老年冠心病心力衰竭患者心功能,減輕機體炎癥反應。
Abstract:
bstract:Objective To investigate the efficacy of metoprolol combined with trimetazidine in the treatment of elderly patients with coronary heart disease and heart failure. Methods 76 patients with coronary heart disease who were admitted to our hospital from August 2016 to September 2018 were enrolled in the study. They were divided into observation group and control group according to the random number table, 38 cases each. Both groups were treated with standardized heart failure treatment. The control group was treated with metoprolol tartrate tablets. The observation group was treated with trimetazidine tablets on the basis of the control group,The levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and clinical efficacy were compared before and after treatment. Results After treatment, the levels of hs-CRP, IL-6 and TNF-α in the two groups decreased, and the observation group was lower than the control group,the difference was statistically significant (P<0.05). The total effective rate of the observation group was 92.11%, which was higher than that of the control group 73.68%,the difference was statistically significant (P<0.05). Conclusion Metoprolol combined with trimetazidine can effectively improve the heart function and reduce the body's inflammatory response in elderly patients with coronary heart disease and heart failure.

參考文獻/References:

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