[1]田 明,常偉平.UbcH10在肝癌中的表達及其與預后的關系[J].醫學信息,2019,(12):77-79.[doi:10.3969/j.issn.1006-1959.2019.12.024]
 IAN Ming,CHANG Wei-ping.Expression of UbcH10 in Hepatocellular Carcinoma and Its Relationship with Prognosis[J].Medical Information,2019,(12):77-79.[doi:10.3969/j.issn.1006-1959.2019.12.024]
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UbcH10在肝癌中的表達及其與預后的關系()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年12期
頁碼:
77-79
欄目:
論著
出版日期:
2019-06-15

文章信息/Info

Title:
Expression of UbcH10 in Hepatocellular Carcinoma and Its Relationship with Prognosis
文章編號:
1006-1959(2019)12-0077-03
作者:
田 明常偉平
西安醫學院第一附屬醫院普外科,陜西 西安 710000
Author(s):
IAN MingCHANG Wei-ping
Department of General Surgery,the First Affiliated Hospital of Xi'an Medical College,Xi'an 710000,Shaanxi,China
關鍵詞:
UbcH10肝癌預后
Keywords:
Key words:UbcH10Liver cancerPrognosis
分類號:
R735.7
DOI:
10.3969/j.issn.1006-1959.2019.12.024
文獻標志碼:
A
摘要:
目的 探討UbcH10在肝癌中的臨床病理特征及預后意義。方法 采用RT-PCR技術對我院2017年9月~12月收治的30例不同分化程度肝癌患者腫瘤組織中的UbcH10表達進行檢測,通過Kaplan-Meier和 Cox回歸評估UbcH10表達與患者存活率的相關性。結果 低分化肝癌組織中UbcH10 mRNA表達EI評分為(0.82±0.32)分,高于高分化癌組織的(0.33±0.06)分,差異有統計學意義(P<0.05);不同組織學分化程度和淋巴結轉移患者的UbcH10表達比較,差異有統計學意義(P<0.05);高UbcH10表達和低UbcH10表達的肝癌患者的存活時間不同,差異有統計學意義(P<0.05)。結論 UbcH10可能在腫瘤發展中起積極作用,可作為肝癌患者預后不良的獨立預測因子。
Abstract:
Abstract:Objective To investigate the clinicopathological features and prognostic significance of UbcH10 in hepatocellular carcinoma. Methods The expression of UbcH10 in tumor tissues of 30 patients with different degrees of differentiation from September to December 2017 was detected by RT-PCR.Correlation between UbcH10 expression and patient survival was assessed by Kaplan-Meier and Cox regression. Results The EI score of UbcH10 mRNA expression in poorly differentiated liver cancer tissues was (0.82±0.32), which was higher than that in well differentiated cancer tissues(0.33±0.06), the difference was statistically significant (P<0.05).The difference of UbcH10 expression between patients with different histological differentiation and lymph node metastasis was statistically significant (P<0.05). The survival time of patients with high UbcH10 expression and low UbcH10 expression was different,the difference was statistically significant (P<0.05). Conclusion UbcH10 may play an active role in tumor development and may be an independent predictor of poor prognosis in patients with liver cancer.

參考文獻/References:

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更新日期/Last Update: 2019-06-15
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